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Laser texturation for improved osteointegration of Titanium implants

Thursday (25.06.2020)
15:20 - 15:40 Room 3
Part of:

Titanium is a well known and a widely used metal in medical applications because of its extreme biocompatibility, its excellent corrosion resistance and good mechanical properties. But it is also relatively inert toward cell interaction. In some cases, implant shows long term failure because of an insufficient integration toward bone [ ].

Numerous studies were undertaken to improve its interaction with cell by different means – one of them is the control of the implant surface as it is one of the critical factor for appropriate osteointegration. It has been shown that cell interactions with the implant largely are largely influenced by several factors such as the chemistry, the roughness at both micro and nanoscale, the presence of sharp motif, or the size of topographic feature [ ].

Several chemical and physical routes are existing to improve the osteointegration. For example, modifying the surface chemistry of the material to bring on more polar and hydrophilic functions has been widely used in industries. As well, increasing the contact surface available by means of increasing macro and micro-roughness is commonly used method [ ].

Acid etching or anodization are common method used as chemical treatment. It is a very efficient and aggressive method. However the acid used are quite dangerous and there is a risk of residual amount being not properly removed with the cleaning of the material. These acids could induce a toxic reaction with the body. Blasting is a physical common method. It has harsh impact on the surface of the metal.


Femtosecond laser texturing seems to be a good alternative route as it does not imply any chemical and do not produce dust or particles during its processing. In terms of risk and regulatory point of view this is an important advantage. Furthermore in contrary of acid etching or grit blasting the created topography with laser might be oriented to guide the cell re-colonization of the surface. Authors reported the influence of the dimension of the texture on cell attachment and adhesion [ , ].

Nanotechnology are investigated nowadays because of their ability to mimic cellular environment and therefore contribute in a better adhesion. Surface roughness of bone would be approximately 32 nm making nanotopography in the same scale as the bone.

The present study present the impact of process parameter on the topography of the textured surface, the polarity and the cell behavior of Titanium based alloy .

Additional Authors:
  • Konstantin Sipos
  • Dr. Ainara Rodriguez
  • Dr. Reine Bareille
    CIC 1401, CHU Bordeaux, Inserm ; Univ. Bordeaux


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