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Student High-Volume 2PP Structures as Ground Truth Phantoms for Diffusion Magnetic Resonance Imaging

Thursday (25.06.2020)
09:20 - 09:40 Room 3
Part of:

2-Photon Polymerization (2PP) takes advantage of nonlinear absorption of femtosecond laser pulses to induce cross-linking, in order to create 3D structures with a high temporal and spatial control, thereby enabling spatial resolution in the sub-micrometer range (down to < 100 nm). Diffusion weighted imaging (DWI) is an important scientific and diagnostic tool based on non-invasive characterization of multiscale diffusion processes. Complex models for analyzing the DWI data are proposed. To test those models a well-defined diffusion phantom, a so called ground truth phantom, with a known design is needed. Combining up-scaling techniques with the high-resolution nature of 2PP allows it to create such phantoms with complex networks of channels that resemble axons and are suitable for DWI.

Additional Authors:
  • Michael Woletz
    Medical University of Vienna
  • Benedikt Hager
    Medical University of Vienna
  • Dr. Siawoosh Mohammadi
    University Medical Center Hamburg-Eppendorf
  • Dr. Zoltan Nagy
    University of Zurich
  • Prof. Dr. Aleksandr Ovsianikov
    TU Wien
  • Prof. Dr. Christian Windischberger
    Medical University of Vienna