Fabrication of thin films as a drug delivery tool via Laser-Induced Forward TransferThursday (25.06.2020) 09:40 - 10:00 Room 1
The use of different 3D printing technologies for pharmaceutical manufacturing provides new opportunities for personalized medicine and on-demand tailored drug products, such as implants and other dosage forms. In this work we present our recent achievements in developing a viable manufacturing process for printed personalized dosage forms onto thin films. Laser Induced Forward Transfer (LIFT) printing technology has been successfully applied by means of a 355 nanosecond laser to deposit active substances starting from solutions in a wide range of viscosities (Figure 1). The main advantage of LIFT printing lies in the preparation of thin films as dosage forms, each with different designs, multiple actives and sizes. In the context of investigating the effectiveness of the LIFT printing, a Mass Spectrometry (MS)-based analytical technique was developed and applied for the study of paclitaxel printed with LIFT on thin potato starch wafer paper and glass substrates. The active pharmaceutical ingredient (API) quantification of the LIFT-printed dosage forms was confirmed using a High-Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS) analysis. The obtained thin films were characterized regarding their recovery, disintegration time and homogeneity. The final aim will be to develop slow release skin patches containing paclitaxel which will be applied transdermally.
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